【兴大报告 Xing Da Lecture 538】

发布时间：2017-11-16　　　来源:北大化学


题  目

Recent Advances in Carbene Chemistry: Concepts and Applications


报告人

Prof. Alois Fürstner

Max-Planck-Institut für Kohlenforschung, Germany


时　间

2017年11月24日，下午2:00


地　点

化学楼A204/206

 

主请人

王剑波




A

BSTRACT

报告摘要

This lecture intends to showcase some unconventional ways of harnessing the reactivity of alkynes via highly selective metal-catalyzed transformations. After a short review of our work in the area of triple bond metathesis, some unorthodox addition reactions to internal alkynes will be discussed in detail. 


    The use of carbophilic Lewis acids based on gold, platinum or rhodium provides many opportunities for the selective functionalization of triple bonds. Although it is well accepted that the reactions usually proceed via metal carbene intermediates, the actual nature of such species was subject to speculation. Only recently has our group managed to isolate reactive carbenes of gold and rhodium. The structural features of these species and the preparative implications will be discussed in some detail.


    Moreover, unprecedented ruthenium-catalyzed trans-hydrogenation, trans-hydroboration and trans-hydrostannation reactions will be presented. These unconventional transformations are also thought to proceed via metal-carbene intermediates, some of which have also been isolated and fully characterized. Selected applications to target-oriented synthesis are meant to showcase the current state of development. 


★ Professor Alois Fürstner ★

Alois Fürstner教授是德国有机化学领域的顶尖科学家，在世界范围内享有很高的声誉。Fürstner教授的研究涉及有机化学的多个领域：烯烃以及炔烃的复分解反应，－酸催化，铁催化，天然产物全合成等。Fürstner教授获得过多个重要的国际奖项，他曾经担任过德国马普所的常务所长（Managing Director），以及目前担任Angewandte Chemie杂志编委会主席。


    Alois Fürstner’s scientific interests relate to organometallic chemistry and homogenous catalysis, including applications thereof to target oriented synthesis. An early success was the development of the first NHK-reactions catalytic in chromium. Further notable lines of research comprise extensive studies on alkene- and alkyne metathesis, pioneering contributions to the field of -acid catalysis based on platinum and gold, as well as the development and mechanistic investing of iron-catalyzed reactions. These methods opened concise and flexible entries into many bioactive natural products.


    His research was recognized by several awards, including the Leibniz Award of the German Science Foundation (1999), the IUPAC-Thieme Prize (2000), an ACS Arthur C. Cope Scholar Award (2002), the inaugural Mukaiyama Award (Japan, 2005), the Otto-Bayer-Prize of the German Chemical Society (2013), the Gay-Lussac/Humboldt Prize (France, 2014), and the ACS H. C. Brown Award (2016).

 

Vita

  • 2009-2011  Managing Director of the Max-Planck-Institut für Kohlenforschung

  • since 1998  Director at the Max-Planck-Institut für Kohlenforschung and Professor at the Technical University of Dortmund

  • 1993-1998  Group leader at the Max-Planck-Institut für Kohlenforschung and Lecturer at the University of Dortmund

  • 1992   “Habilitation” in Organic Chemistry at the Technical University Graz, Austria

  • 1990-1991  Postdoctoral fellow at the University of Geneva, Switzerland (W. Oppolzer)

  • 1987  PhD at the Technical University Graz, Austria (H. Weidmann)

  • 1962  born in Bruck/Mur (Austria)